Genetic basis of male fertility

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Genetic basis of male fertility.

We are in the age of genetic discovery. Now the human genome has been completely sequenced1, there will be increasing understanding and ability to manipulate biochemical pathways downstream of genes. At the same time, further development of in vitro fertilization (IVF) and intracytoplasmic sperm injection(ICSI) will enable procreation in situations that were formerly impossible and when there m...

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Symposium: Genetic aspects of male (in)fertility

The Y chromosomal azoospermia factor (AZF) is essential for human spermatogenesis. It has been mapped by molecular deletion analyses to three subintervals in Yq11, AZFa, AZFb, and AZFc, containing a number of genes of which at least some control, post-transcriptionally, the RNA metabolism of other spermatogenesis genes, functionally expressed at different phases of the spermatogenic cycle. Intr...

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The genetic basis of male fertility in relation to haplodiploid reproduction in Leptopilina clavipes (Hymenoptera: Figitidae).

Traits under relaxed selection are expected to become reduced or disappear completely, a process called vestigialization. In parthenogenetic populations, traits historically involved in sexual reproduction are no longer under selection and potentially subject to such reduction. In Leptopilina clavipes, thelytokous (parthenogenetic) populations are infected by Wolbachia bacteria. Arrhenotokous p...

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Genetic basis of male sexual behavior.

Male sexual behavior is increasingly the focus of genetic study in a variety of animals. Genetic analysis in the soil roundworm Caenorhabditis elegans and the fruit fly Drosophila melanogaster has lead to identification of genes and circuits that govern behaviors ranging from motivation and mate-searching to courtship and copulation. Some worm and fly genes have counterparts with related functi...

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Genetic basis of male pattern baldness.

Common pattern baldness (androgenetic alopecia) is the most common form of hair loss in humans. In Caucasians, normal male hair loss, commonly known as ‘‘male pattern baldness’’ (MPB; MIM 109200), is noticeable in about 20% of men aged 20, and increases steadily with age, so that a male in his 90s has a 90% chance of having some degree of MPB. In addition to being among the most common natural ...

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ژورنال

عنوان ژورنال: British Medical Bulletin

سال: 2000

ISSN: 0007-1420,1471-8391

DOI: 10.1258/0007142001903454